{"cross_mech":[],"family":{"alphafold_models":23,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a member of a biosynthetic gene cluster (BGC) involved in duramycin biosynthesis, a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by various actinomycetes and marine symbionts. Duramycin binds phosphatidylethanolamine (PE), a major structural phospholipid in mammalian and microbial cell membranes which contains 19 amino acids and 5 post-translational modifications (PTMs). This entry represents DurN, an enzyme that forms (2S,9S)-Lal one of the two last PTMs. DurN catalyses stereospecific and diastereoselective Lal formation in an unusual substrate-assisted mechanism in which the active site residues that make the reaction proceed come from the substrate itself, manoeuvred into position by DurN [[cite:PUB00152101]].","domain_architectures":1,"interpro_id":"IPR045994","known_evidence_count":null,"matches":42,"name":"DurN substrate-assisted peptide maturase","partial_evidence_count":null,"pfam_id":"PF19375","proteins":42,"proteomes":38,"short_name":"DurN","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19375","structures":3,"taxa":81,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF19375.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":23,"domain_architectures":1,"matches":42,"proteins":42,"proteomes":38,"structures":3,"taxa":81},"curation_status":"SEEDED","description":"This entry represents a member of a biosynthetic gene cluster (BGC) involved in duramycin biosynthesis, a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by various actinomycetes and marine symbionts. Duramycin binds phosphatidylethanolamine (PE), a major structural phospholipid in mammalian and microbial cell membranes which contains 19 amino acids and 5 post-translational modifications (PTMs). This entry represents DurN, an enzyme that forms (2S,9S)-Lal one of the two last PTMs. DurN catalyses stereospecific and diastereoselective Lal formation in an unusual substrate-assisted mechanism in which the active site residues that make the reaction proceed come from the substrate itself, manoeuvred into position by DurN [[cite:PUB00152101]].","id":"Pfam:PF19375","interpro_id":"InterPro:IPR045994","name":"DurN substrate-assisted peptide maturase","pfam_id":"PF19375","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"DurN","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19375"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF19375.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"121110e013dd1c0e5c4ac0b8867181bc4f7d5c9f1e926f6bc50c17240c71bbb9"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF19375","short_name":"DurN","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}