{"cross_mech":[],"family":{"alphafold_models":1075,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry (ex DUF6079) represents the P-loop domain at the N-terminal in Probable ATP-binding protein BrxC and ATPase pglY. BrxC is a core protein of a type 1 BREX system, which provides immunity against bacteriophage. The ATPase PglY is part of a type 2 BREX system, which provides immunity against bacteriophage infections [[cite:PUB00093365],[cite:PUB00161155],[cite:PUB00151239],[cite:PUB00105105]]. PglY hydrolyses ATP but not other nucleotides, and its activity is inhibited by the non-hydrolysable ATP analogue 5-adenylyl beta,gamma-imidodiphosphate.","domain_architectures":34,"interpro_id":"IPR045725","known_evidence_count":null,"matches":1899,"name":"BrxC/PglY, N-terminal domain","partial_evidence_count":null,"pfam_id":"PF19557","proteins":1880,"proteomes":1736,"short_name":"BrxC-PglY_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19557","structures":3,"taxa":3488,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF19557.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1075,"domain_architectures":34,"matches":1899,"proteins":1880,"proteomes":1736,"structures":3,"taxa":3488},"curation_status":"SEEDED","description":"This entry (ex DUF6079) represents the P-loop domain at the N-terminal in Probable ATP-binding protein BrxC and ATPase pglY. BrxC is a core protein of a type 1 BREX system, which provides immunity against bacteriophage. The ATPase PglY is part of a type 2 BREX system, which provides immunity against bacteriophage infections [[cite:PUB00093365],[cite:PUB00161155],[cite:PUB00151239],[cite:PUB00105105]]. PglY hydrolyses ATP but not other nucleotides, and its activity is inhibited by the non-hydrolysable ATP analogue 5-adenylyl beta,gamma-imidodiphosphate.","id":"Pfam:PF19557","interpro_id":"InterPro:IPR045725","name":"BrxC/PglY, N-terminal 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ATP-binding protein 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coli O9:H4 (strain HS)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/brex-brxc-4th-pf25796.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF25796","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/brex-brxc-4th-pf25796.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/brex-brxc-helical-pf25792.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF25792","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/brex-brxc-helical-pf25792.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/brxc-pgly-n-pf19557.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF19557","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/brxc-pgly-n-pf19557.yaml"}],"pfam_ids":["PF19557","PF25791","PF25792","PF25796"],"protein_name":"Probable ATP-binding protein 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