{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF20041","protein_label":"","reviewed":null,"short_name":"DUF6443","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf6443-ipr045619.yaml","source_record_id":"InterPro:IPR045619","source_record_label":"Domain of unknown function DUF6443","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF20041","protein_label":"","reviewed":null,"short_name":"DUF6443","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf6443-pf20041.yaml","source_record_id":"Pfam:PF20041","source_record_label":"Domain of unknown function (DUF6443)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":752,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This presumed domain is functionally uncharacterised. This domain family is predominantly found in Bacteroidetes, and is about 100 amino acids in length. This domain contains a highly conserved YDxxGR motif which suggests that it is related the RHS repeats, that appear to be involved in ligand binding. RHS repeats share structural similarity with the eukaryotic tyrosine-aspartate (YD) repeat [[cite:PUB00070343]].","domain_architectures":258,"interpro_id":"IPR045619","known_evidence_count":null,"matches":2128,"name":"Domain of unknown function (DUF6443)","partial_evidence_count":null,"pfam_id":"PF20041","proteins":2105,"proteomes":812,"short_name":"DUF6443","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20041","structures":0,"taxa":1303,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF20041.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":752,"domain_architectures":258,"matches":2128,"proteins":2105,"proteomes":812,"structures":0,"taxa":1303},"curation_status":"SEEDED","description":"This presumed domain is functionally uncharacterised. This domain family is predominantly found in Bacteroidetes, and is about 100 amino acids in length. This domain contains a highly conserved YDxxGR motif which suggests that it is related the RHS repeats, that appear to be involved in ligand binding. RHS repeats share structural similarity with the eukaryotic tyrosine-aspartate (YD) repeat [[cite:PUB00070343]].","id":"Pfam:PF20041","interpro_id":"InterPro:IPR045619","name":"Domain of unknown function (DUF6443)","pfam_id":"PF20041","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF6443","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20041"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF20041.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"904e2e9b60ecb7eba98e9e4908580018d772fac1e13d81937d42136af667a6c9"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF20041","short_name":"DUF6443","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}
