{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml","source_record_id":"InterPro:IPR048317","source_record_label":"DUF5581, Fn3-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q80WB0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml","source_record_id":"InterPro:IPR048317","source_record_label":"DUF5581, Fn3-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9BVV2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml","source_record_id":"InterPro:IPR049231","source_record_label":"DUF5581, N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q80WB0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml","source_record_id":"InterPro:IPR049231","source_record_label":"DUF5581, N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9BVV2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF20996","protein_label":"","reviewed":null,"short_name":"DUF5581_N","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml","source_record_id":"InterPro:IPR049231","source_record_label":"DUF5581, N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","source_record_id":"Pfam:PF17744","source_record_label":"Family of unknown function (DUF5581) Fn3-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9913","taxon_label":"Bos taurus","uniprot_accession":"Q2T9Z2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","source_record_id":"Pfam:PF17744","source_record_label":"Family of unknown function (DUF5581) Fn3-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q80WB0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","source_record_id":"Pfam:PF17744","source_record_label":"Family of unknown function (DUF5581) Fn3-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9BVV2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","source_record_id":"Pfam:PF20996","source_record_label":"Family of unknown function (DUF5581) N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9913","taxon_label":"Bos taurus","uniprot_accession":"Q2T9Z2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","source_record_id":"Pfam:PF20996","source_record_label":"Family of unknown function (DUF5581) N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q80WB0","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF20996","protein_label":"Fibronectin type III domain-containing protein 11","reviewed":true,"short_name":"DUF5581_N","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","source_record_id":"Pfam:PF20996","source_record_label":"Family of unknown function (DUF5581) N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9BVV2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF20996","protein_label":"","reviewed":null,"short_name":"DUF5581_N","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","source_record_id":"Pfam:PF20996","source_record_label":"Family of unknown function (DUF5581) N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":354,"candidate_reasons":["name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":4},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the N-terminal helical domain found in C20orf195 and its homologues found in chordates.","domain_architectures":3,"interpro_id":"IPR049231","known_evidence_count":null,"matches":397,"name":"Family of unknown function (DUF5581) N-terminal domain","partial_evidence_count":null,"pfam_id":"PF20996","proteins":397,"proteomes":362,"short_name":"DUF5581_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20996","structures":0,"taxa":1216,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF20996.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":354,"domain_architectures":3,"matches":397,"proteins":397,"proteomes":362,"structures":0,"taxa":1216},"curation_status":"SEEDED","description":"This entry represents the N-terminal helical domain found in C20orf195 and its homologues found in chordates.","id":"Pfam:PF20996","interpro_id":"InterPro:IPR049231","name":"Family of unknown function (DUF5581) N-terminal domain","pfam_id":"PF20996","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF5581_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20996"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF20996.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a0c84d9e0844d7f0067e2e603d7d2533b722410db7d643b45578e9755ed46da1"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bos taurus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17744","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf5581-pf17744.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF20996","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml"}],"pfam_ids":["PF17744","PF20996"],"protein_name":"Fibronectin type III domain-containing protein 11","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNFQVTGLGLDKIKLDSPQSFLDQEEVEEAEDGQLLEPEAWRTYVERRNALQEFLTSDLSPHLLKRHHARMELLKKCSYYIEILPKHLALGDQNPLVLPTTMFQLIDPWKFQRMKKVGAAQTKIQLLLLGDLLEQLDHGRSELDALLESPDPRPFLAGWGLVEQRLADLSAVMDSFLAMMVPGRLHIKHRLVSDIGATKIPHIRLMLSTKMPVMFDRKESVAHQDWVSLRWFVTIQQAVPEQFELRYKLLDPRTQQECMQCGIIPVAACAFDIRNLLPNRAYKFTVKRAESYTLVYEPWRDSLTLHTRPGPPEGLAPSRLGKLGLSLTTPSER","sequence_length":333,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f66ad61813fc201196846f9d4ac11ae4d52a62a224259e4a815cb0ebe0769114","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q2T9Z2.json","taxon_id":"9913","uniprot_accession":"Q2T9Z2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048317","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR049231","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17744","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf5581-pf17744.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF20996","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml"}],"pfam_ids":["PF17744","PF20996"],"protein_name":"Fibronectin type III domain-containing protein 11","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNFQVTGLALDKMKLDSPHSFLDAEEVEEAEDQQLLEPEAWRTYMERRNVLREFLTTDLSPQLLKRHHARMQLLKKCSYYIEILPKHLALGDQNPLVLPNTMFQLIDPWKFQRMKKVGTAQTKIQLLLLGDLLEQLDHGRAALDALLEAPDPRPFLAGWGLVEQQLADLSVVMDNFLAMMVPGHLHVKHRLVSDIGATKIPHIRLMLSTKMPVMFDRKESVAHQDWVSLRWFVTIQPAAPEQYELRFKLLEPRTQQECTQCGIVPVAACTFDVHNLLPNRTYKFTIKRAESYTLVYEPWRDSLTLQTTPGPPEGPAPRLGEPPAGL","sequence_length":326,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ad1f08124914fa5f6e6ee00bf0f129be5f5e23e00c9405ea6c81ccc523139aa9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q80WB0.json","taxon_id":"10090","uniprot_accession":"Q80WB0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048317","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf5581-fn3-like-domain-ipr048317.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR049231","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/duf5581-n-terminal-domain-ipr049231.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf5581-pf17744.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17744","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf5581-pf17744.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF20996","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf5581-n-pf20996.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9BVV2","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF17744","PF20996"],"protein_name":"Fibronectin type III domain-containing protein 11","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"2fe98ae62335e17b4fbcd86972b84b494e41452d025b42849515831078c95a26","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSTHVAGLGLDKMKLGNPQSFLDQEEADDQQLLEPEAWKTYTERRNALREFLTSDLSPHLLKRHHARMQLLRKCSYYIEVLPKHLALGDQNPLVLPSALFQLIDPWKFQRMKKVGTAQTKIQLLLLGDLLEQLDHGRAELDALLRSPDPRPFLADWALVERRLADVSAVMDSFLTMMVPGRLHVKHRLVSDVSATKIPHIWLMLSTKMPVVFDRKASAAHQDWARLRWFVTIQPATSEQYELRFRLLDPRTQQECAQCGVIPVAACTFDVRNLLPNRSYKFTIKRAETSTLVYEPWRDSLTLHTKPEPLEGPALSHSV","sequence_length":318,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"2fe98ae62335e17b4fbcd86972b84b494e41452d025b42849515831078c95a26","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9BVV2.json","taxon_id":"9606","uniprot_accession":"Q9BVV2","uniprot_release":"2026_03"}],"pfam_id":"PF20996","short_name":"DUF5581_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}