{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF24034","protein_label":"Uncharacterized protein MJ1254","reviewed":true,"short_name":"DUF7343","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf7343-ipr055767.yaml","source_record_id":"InterPro:IPR055767","source_record_label":"Domain of unknown function DUF7343","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58651","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF24034","protein_label":"","reviewed":null,"short_name":"DUF7343","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf7343-ipr055767.yaml","source_record_id":"InterPro:IPR055767","source_record_label":"Domain of unknown function DUF7343","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF24034","protein_label":"Uncharacterized protein PH0614","reviewed":true,"short_name":"DUF7343","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/cw-binding-2-pf04122.yaml","source_record_id":"Pfam:PF04122","source_record_label":"Cell wall binding domain 2 (CWB2)","source_section":"canonical_examples","taxon_id":"NCBITaxon:70601","taxon_label":"Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)","uniprot_accession":"O58348","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF24034","protein_label":"Uncharacterized protein PH0614","reviewed":true,"short_name":"DUF7343","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","source_record_id":"Pfam:PF24034","source_record_label":"Domain of unknown function (DUF7343)","source_section":"canonical_examples","taxon_id":"NCBITaxon:70601","taxon_label":"Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)","uniprot_accession":"O58348","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF24034","protein_label":"Uncharacterized protein MJ1254","reviewed":true,"short_name":"DUF7343","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","source_record_id":"Pfam:PF24034","source_record_label":"Domain of unknown function (DUF7343)","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58651","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF24034","protein_label":"Uncharacterized protein PYRAB14350","reviewed":true,"short_name":"DUF7343","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","source_record_id":"Pfam:PF24034","source_record_label":"Domain of unknown function (DUF7343)","source_section":"canonical_examples","taxon_id":"NCBITaxon:272844","taxon_label":"Pyrococcus abyssi (strain GE5 / Orsay)","uniprot_accession":"Q9UYS2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF24034","protein_label":"","reviewed":null,"short_name":"DUF7343","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","source_record_id":"Pfam:PF24034","source_record_label":"Domain of unknown function (DUF7343)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1582,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the HTH domain found in group of uncharacterised archaeal proteins.","domain_architectures":27,"interpro_id":"IPR055767","known_evidence_count":null,"matches":1726,"name":"Domain of unknown function (DUF7343)","partial_evidence_count":null,"pfam_id":"PF24034","proteins":1726,"proteomes":597,"short_name":"DUF7343","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24034","structures":0,"taxa":1135,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF24034.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1582,"domain_architectures":27,"matches":1726,"proteins":1726,"proteomes":597,"structures":0,"taxa":1135},"curation_status":"SEEDED","description":"This entry represents the HTH domain found in group of uncharacterised archaeal proteins.","id":"Pfam:PF24034","interpro_id":"InterPro:IPR055767","name":"Domain of unknown function (DUF7343)","pfam_id":"PF24034","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF7343","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24034"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF24034.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2d8d5d08a6768f0bb53b046462f9bac75d6c4d37dccec9465ed4cbbfe95b17e9"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cw-binding-2-pf04122.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF04122","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cw-binding-2-pf04122.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF24034","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf7343-pf24034.yaml"}],"pfam_ids":["PF04122","PF24034"],"protein_name":"Uncharacterized protein PH0614","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKRIPSLIIGLLLILATWHSVLAINDNYDLIIVRNDDLIDYLISLPYSHLINAPILPVNPKELDPVTKAQLYSYIQLGRDKVLIIGNTNAVSLDVEKELRDMGFSVTRIGGADRAETAEKLALHFYQNGSKVVILASAWDYGSTLAAAEFAMEYKCPILLTWENQLSPSALRGIEKLNAKIVILVGFGINETIEKTLEGMGYETYWIGRDIEPPPIETTTSSPPQSSGSKSFFLGMIVTLIILAPVILYLWRRRSERMSEFLEQFNEKELAVLKAIMERGGEVKQEDLPRIVGYSRPTISRIVQDLEKKGIVEREKSGKTFIVRVIKKIKID","sequence_length":332,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"97da1ff49e4f2e8e72b7982f57bf94e0c202889c723e8a70af72ef5d6fd90df7","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/O58348.json","taxon_id":"70601","uniprot_accession":"O58348","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf7343-ipr055767.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR055767","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf7343-ipr055767.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF24034","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf7343-pf24034.yaml"}],"pfam_ids":["PF24034"],"protein_name":"Uncharacterized protein MJ1254","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIAFLFYKCFAKNYKINFLYKNSSYINTNTLWLKVIYIKTKDVIIFLLLFFVAFNVSSAYVIKNLNIDCIVTPDDTINETISFVIYNNEDKNLSHISYTIPQTIRNFTINASAGVKGYSALYNEGVTEIAIEFEKPIPKGGYTNITINCFVNDAIWTKNGIKQLILSFPITSKNATIKIVLPPGAVILSPQGTLLVTPSGYKITTDGKHQIIVWDLSLNKEITFTITVKYTFISYPGQNIIEQPAINNNLKYLLIIAIFGTAIFGGLFVKEKISKRKIIERTKNIKNELTSLKNKLKEKEEEIKNLAIKIKDLEDKLSKANKNLLNKDEIISVLNERISEYESQIQKLLDENIIYKEKIESLNKYIETLKKENDKLKDKVRELSDIAKKYMEEKRGVLWSFLTEDEKIIIDLIKKHGHITQKEIVEITGMSKPKVSRIISELEDRKIIRKEKIGRINKLTLTEESKKLL","sequence_length":469,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"59cb66ac8fca0a7fc3ce866e153030caeb05b2dc25a27b2c0437637b396e538f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58651.json","taxon_id":"243232","uniprot_accession":"Q58651","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Pyrococcus abyssi (strain GE5 / Orsay)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf7343-pf24034.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF24034","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf7343-pf24034.yaml"}],"pfam_ids":["PF04122","PF24034"],"protein_name":"Uncharacterized protein PYRAB14350","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSRSFMIILTIMLIALSLGEVLAAENGYDLIIVRNDDLIDYLIALPYSHLLDIPILPVNPKELDDVTKAQLYSYIQLGRDKILIIGNNNAVSLNVEKELEDMGFKVTRIGGADRTETAEKLALHFYPNGSKLVILASAWDYGSTLAASEFAMEYKCPILLTWENQLSPSALEGIKKLNPKIVILVGFGINETVEKTIEDMGYETYWIGRDIEPPPIETTTTTTPNQTSSSKSFFLGVLVTLMILSPVIVYLWKKREERRSQFLEQFSEKEIEVLRAIIENGGEIKQEELPKIVGYSRPTISRIIQDLEKKGIVEREKSGKTFIVRVIKKIKLD","sequence_length":333,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"76e5ede360084ffd95b20467a910243c75712193e60c8b335e10199e5b6b4f1e","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9UYS2.json","taxon_id":"272844","uniprot_accession":"Q9UYS2","uniprot_release":"2026_03"}],"pfam_id":"PF24034","short_name":"DUF7343","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}