{"cross_mech":[],"family":{"alphafold_models":89,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found at the C-terminal of Ras guanine nucleotide exchange factor glfB from Dictyostelium discoideum and in similar uncharacterised proteins from lower eukaryotes. GflB is a GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signalling at the leading edge of chemotaxing cells [[cite:PUB00159973],[cite:PUB00159975]]. This protein also acts as a key regulator of antin -driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signalling pathways [[cite:PUB00159974]]. This domain is predicted to adopt a globular a/b structure.","domain_architectures":13,"interpro_id":"IPR056651","known_evidence_count":null,"matches":114,"name":"GlfB-like, C-terminal domain","partial_evidence_count":null,"pfam_id":"PF24929","proteins":107,"proteomes":28,"short_name":"GlfB_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24929","structures":0,"taxa":127,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF24929.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":89,"domain_architectures":13,"matches":114,"proteins":107,"proteomes":28,"structures":0,"taxa":127},"curation_status":"SEEDED","description":"This domain is found at the C-terminal of Ras guanine nucleotide exchange factor glfB from Dictyostelium discoideum and in similar uncharacterised proteins from lower eukaryotes. GflB is a GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signalling at the leading edge of chemotaxing cells [[cite:PUB00159973],[cite:PUB00159975]]. This protein also acts as a key regulator of antin -driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signalling pathways [[cite:PUB00159974]]. This domain is predicted to adopt a globular a/b structure.","id":"Pfam:PF24929","interpro_id":"InterPro:IPR056651","name":"GlfB-like, C-terminal domain","pfam_id":"PF24929","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"GlfB_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF24929"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF24929.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c81f54e3eb86871a7065a6ea78a7980434934dc79d727108e52e7a512d39eb3a"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Dictyostelium discoideum","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glfb-c-pf24929.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF24929","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glfb-c-pf24929.yaml"}],"pfam_ids":["PF00617","PF00618","PF00620","PF24929"],"protein_name":"Ras guanine nucleotide exchange factor glfB","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTDLNSESFSALNFWKSVEKKNISTNFQGTKVVAPSKKINSFPLLAPPAPPPPPTEQEINIGSGNSTFISSNNNNSNNNNNNNSNNNNNNNLNNSNNNNNNLNSNNNNNNNNNNNNNNGNNNNNSNFLTRQDSSTQKEWDEQNVTEAFGFWKQKAVQLQKETERYNARRNARQTIDLTNILRKSTSSDLLIKPPVESPPLTPVGQDDEGEQQQQQQQQKQSSPSTPSNDTDTETTAAAVTTTTTTTTTTTTSTTTTTTETVLQANQLEIKYGGETIAVVDDSGTTPRDYRRSRSISCEIIPKINGVITTSPQRVTTTTTTTTPSTGGVVVADEESDSSEEESDSSEEESDEYTDEESETELQVVSNATPRRSDDFTPTIVESPPLTSVNSNDNTSSGTVVAPIDLNSSTGGNTGSQQPPQPSSQQQKPDQASENTAVAASSISATTNVTSAASTTTVAPDSIINTKDVTVVSSTLTTTTSATSSTTSATTQSIPAPPSPSQQRAAQSISTSSVTPAAITKPTKDAKDKKDPAKKSIGATLTRTVTKTFIRDSKENNKVPTGTSPPVSSSTSISSSTGIKKDKVKLSKEEKDRIKKEKSAKKKKEKDEKKQQKTNKKALTKNNSSTDVKKGFVSPQQQQILDSPYRIYGVRLTQLVLSNDGDLPAILTQTITVLSNSNKLDVNSVFVGAENEPAVREIRKRSDLERIDFSIIGDPRVVAGLLILFFAELPQPLFNSKFFGDLVEINDITNPQVKLNDLKQLINSLSQLRRSLLQILVTFFTSKYINGNSVTTRAIAIQSIAQSFGPQFFRGTSSSDSDIQVGIETLKLIIDNYVFLFEKTNEPDVKYKNIDGKMIISEGSIDKLIDKATDQYYPYNEKYFSLTFFITHLFFIQPHELADKLITLYRENLDTLETKKKWKKHRRSKKASFINEAVKLWVDYCYKEMREDKELSKKILKGFPHLEAQLASRLSHRTTINDFLKLPKRVHSRTRSASFSDTLLSTGGIGSTSGGIGGGVNNCLLSAMEIAEQCTLVDYDLFTNVRLSDWVRLVQGSVDPQTAPSLSLALKRSTIWAQWAMGEILSTEDKSQRVAIINLLVDVAINCKDLANFNTAISIHTALTNHHIKRLQQTWDSVPKETLNKITQLEQSLQVWLKPDATNPFGVICQSINSACVPNFSILRTILSQIDQKIPTFSNDGSMVNVEKLRTIFGIVVEIQRLQQQRNYTMKPTKLFIQLQDINTVSMDELADLSLKCEPPVSKAKKYNAPADIVDEDWRLKITKTFNKPLATTSVGIDLPRLASSFTFNTTGHKTTPEEKSAYGNKIQDIFHVLVSLAQIESSELETDVREKFTTYIPMSTDPDSDFKRELLKFLDEVCHADNSKLVRVLKCCNQAIIAPVIIEITLNIAKGVPFMDAGGWRILISNINNSNNSVILDKIDEINEDSSNVEKEKLSSSQEQQEQQEQKQQEQQQQQQEPQPLFIRHYKKQRSRSAQSKDFFEFEWFIQLNLDADCKNILSFDLKISNLVFSTDTSPNIRDQLLESFKSYLVSQECVQYINFNENKQPVAAPVTPATTIVTTKEESTTVTSSTTTVVQESVPSTNAE","sequence_length":1601,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c73e31b388f772a75461581d7f7d692824d6c0b75907ccb1dd2255c9960fc4fa","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q54L90.json","taxon_id":"44689","uniprot_accession":"Q54L90","uniprot_release":"2026_03"}],"pfam_id":"PF24929","short_name":"GlfB_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}