{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF25637","protein_label":"","reviewed":null,"short_name":"DUF7942","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf7942-pf25637.yaml","source_record_id":"Pfam:PF25637","source_record_label":"Family of unknown function (DUF7942)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":245,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of uncharacterised bacterial proteins is found mainly in Actinomycetes. Members of this family are predicted to contain three transmembrane helices. A member of this family, SCO4225, is a putative integral membrane protein found in Streptomyces coelicolor, [swissprot:Q9FCE5]. The gene encoding SCO4225 is part of a cluster of genes (phoU to sco4225) that are involved in phosphate regulation and metabolism. This gene cluster is regulated by the two-component system PhoR-PhoP, which responds to phosphate availability in the environment [[cite:PUB00159567]]. The expression of SCO4225 is directly regulated by MacR, a response regulator that binds to a specific sequence in the promoter region of SCO4225. This regulation links SCO4225 to other genes in the MacR regulon, many of which are also membrane proteins [[cite:PUB00159414]].","domain_architectures":2,"interpro_id":"IPR057702","known_evidence_count":null,"matches":654,"name":"Family of unknown function (DUF7942)","partial_evidence_count":null,"pfam_id":"PF25637","proteins":608,"proteomes":487,"short_name":"DUF7942","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25637","structures":0,"taxa":641,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF25637.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":245,"domain_architectures":2,"matches":654,"proteins":608,"proteomes":487,"structures":0,"taxa":641},"curation_status":"SEEDED","description":"This family of uncharacterised bacterial proteins is found mainly in Actinomycetes. Members of this family are predicted to contain three transmembrane helices. A member of this family, SCO4225, is a putative integral membrane protein found in Streptomyces coelicolor, [swissprot:Q9FCE5]. The gene encoding SCO4225 is part of a cluster of genes (phoU to sco4225) that are involved in phosphate regulation and metabolism. This gene cluster is regulated by the two-component system PhoR-PhoP, which responds to phosphate availability in the environment [[cite:PUB00159567]]. The expression of SCO4225 is directly regulated by MacR, a response regulator that binds to a specific sequence in the promoter region of SCO4225. This regulation links SCO4225 to other genes in the MacR regulon, many of which are also membrane proteins [[cite:PUB00159414]].","id":"Pfam:PF25637","interpro_id":"InterPro:IPR057702","name":"Family of unknown function (DUF7942)","pfam_id":"PF25637","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF7942","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF25637"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF25637.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8ad9838fa95664a1cf0ca270e607a7990b7b81f0302b582763250b5df969374f"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF25637","short_name":"DUF7942","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}
