{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26154","protein_label":"Uncharacterized protein YvzG","reviewed":true,"short_name":"DUF8042","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8042-ipr058355.yaml","source_record_id":"InterPro:IPR058355","source_record_label":"Domain of unknown function DUF8042","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"C0H3R9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26154","protein_label":"","reviewed":null,"short_name":"DUF8042","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8042-ipr058355.yaml","source_record_id":"InterPro:IPR058355","source_record_label":"Domain of unknown function DUF8042","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26154","protein_label":"Uncharacterized protein YvzG","reviewed":true,"short_name":"DUF8042","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8042-pf26154.yaml","source_record_id":"Pfam:PF26154","source_record_label":"Domain of unknown function (DUF8042)","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"C0H3R9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26154","protein_label":"Uncharacterized protein TP_0873","reviewed":true,"short_name":"DUF8042","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8042-pf26154.yaml","source_record_id":"Pfam:PF26154","source_record_label":"Domain of unknown function (DUF8042)","source_section":"canonical_examples","taxon_id":"NCBITaxon:243276","taxon_label":"Treponema pallidum (strain DSM 117211 / Nichols)","uniprot_accession":"O83843","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26154","protein_label":"","reviewed":null,"short_name":"DUF8042","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8042-pf26154.yaml","source_record_id":"Pfam:PF26154","source_record_label":"Domain of unknown function (DUF8042)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":881,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents an uncharacterised domain family which forms a four helical bundle structure. This family includes the B. subtilis YvzG protein ([swissprot:C0H3R9]).","domain_architectures":16,"interpro_id":"IPR058355","known_evidence_count":null,"matches":1245,"name":"Domain of unknown function (DUF8042)","partial_evidence_count":null,"pfam_id":"PF26154","proteins":1245,"proteomes":1131,"short_name":"DUF8042","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26154","structures":0,"taxa":1925,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF26154.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":881,"domain_architectures":16,"matches":1245,"proteins":1245,"proteomes":1131,"structures":0,"taxa":1925},"curation_status":"SEEDED","description":"This entry represents an uncharacterised domain family which forms a four helical bundle structure. This family includes the B. subtilis YvzG protein ([swissprot:C0H3R9]).","id":"Pfam:PF26154","interpro_id":"InterPro:IPR058355","name":"Domain of unknown function (DUF8042)","pfam_id":"PF26154","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8042","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26154"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26154.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"66c9348142d72c3973f0bfea3a0474f17ab519fafff69198621715127f4bef74"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8042-ipr058355.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR058355","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8042-ipr058355.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8042-pf26154.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26154","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8042-pf26154.yaml"}],"pfam_ids":["PF26154"],"protein_name":"Uncharacterized protein YvzG","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQDLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKEHFLIHYRKWMLSIHQCMEPFLIN","sequence_length":125,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4d49ddd5a06861fb02b73e20a0600ee729084f4f471614fa512bd6edc213c92d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/C0H3R9.json","taxon_id":"224308","uniprot_accession":"C0H3R9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Treponema pallidum (strain DSM 117211 / Nichols)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8042-pf26154.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26154","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8042-pf26154.yaml"}],"pfam_ids":["PF26154","PF27299"],"protein_name":"Uncharacterized protein TP_0873","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDITINGHTLQYVIEHEKTIGEVLGAIEAACKKEKQTVSAVTVNGRELSANELDTLFCQSLDTDVTLNLTTLSGGDVRALLREISTTLLARTAALQEIAVNMHSGNLAESYAMVSDFSALLKSLYHCFTLSDIADLDHGLRIKGKALHDYQREISPLLKGLLEAMEEGDSVAVGDIAEYELAPVVRDLSDGILHMDMGVQ","sequence_length":200,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1857942530956899fa15ad7b0ec69af53c25049709136dabf2f40e52f10b4021","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O83843.json","taxon_id":"243276","uniprot_accession":"O83843","uniprot_release":"2026_03"}],"pfam_id":"PF26154","short_name":"DUF8042","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}