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The domain is sometimes found in association with other domains involved in replication, but specific domain associations are not consistently observed across all members of this family.","domain_architectures":2,"interpro_id":"IPR058461","known_evidence_count":null,"matches":35,"name":"Domain of unknown function (DUF8148) N-terminal domain","partial_evidence_count":null,"pfam_id":"PF26473","proteins":35,"proteomes":26,"short_name":"DUF8148","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26473","structures":0,"taxa":62,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF26473.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":24,"domain_architectures":2,"matches":35,"proteins":35,"proteomes":26,"structures":0,"taxa":62},"curation_status":"SEEDED","description":"This entry represents the N-terminal winged helix domain from a family of uncharacterised proteins found predominantly in archaea, specifically within the Halobacteria class. The proteins in this family are typically found in species such as Halovenus, Halobellus, and Natrarchaeobaculum, among others. Additionally, some members are associated with viruses like the Pleolipoviridae family. The proteins containing this domain are predicted to be involved in replication processes, although their exact function remains unknown. The domain is found in proteins that are generally around 600-700 amino acids in length. These proteins are primarily associated with replication functions, as indicated by their presence in replication proteins across various archaeal species and viruses. The domain is sometimes found in association with other domains involved in replication, but specific domain associations are not consistently observed across all members of this family.","id":"Pfam:PF26473","interpro_id":"InterPro:IPR058461","name":"Domain of unknown function (DUF8148) N-terminal domain","pfam_id":"PF26473","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8148","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26473"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26473.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c52a8bb446bf578522edb1be9f652156b5cf7e1450798bbfea2ec7d0e946512c"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF26473","short_name":"DUF8148","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}