{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26506","protein_label":"","reviewed":null,"short_name":"DUF8574","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8168-ipr058481.yaml","source_record_id":"InterPro:IPR058481","source_record_label":"Domain of unknown function DUF8168","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26506","protein_label":"","reviewed":null,"short_name":"DUF8574","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8574-pf26506.yaml","source_record_id":"Pfam:PF26506","source_record_label":"Domain of unknown function (DUF8574)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":81,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in members of the Halobacteria class, including families such as Haloarculaceae, Natrialbaceae, and Haloferacaceae. The domain is typically found in proteins ranging from approximately 240 to 300 amino acids in length. This domain shows structural similarity to the Csm1 protein covering the HD-like domain and domain A [[cite:PUB00091420]]. This finding suggests that this domain may have DNase activity.","domain_architectures":1,"interpro_id":"IPR058481","known_evidence_count":null,"matches":94,"name":"Domain of unknown function (DUF8574)","partial_evidence_count":null,"pfam_id":"PF26506","proteins":94,"proteomes":75,"short_name":"DUF8574","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26506","structures":0,"taxa":143,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF26506.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":81,"domain_architectures":1,"matches":94,"proteins":94,"proteomes":75,"structures":0,"taxa":143},"curation_status":"SEEDED","description":"This entry represents a domain from a family of uncharacterised proteins in archaea. The proteins containing this domain are predominantly found in members of the Halobacteria class, including families such as Haloarculaceae, Natrialbaceae, and Haloferacaceae. The domain is typically found in proteins ranging from approximately 240 to 300 amino acids in length. This domain shows structural similarity to the Csm1 protein covering the HD-like domain and domain A [[cite:PUB00091420]]. This finding suggests that this domain may have DNase activity.","id":"Pfam:PF26506","interpro_id":"InterPro:IPR058481","name":"Domain of unknown function (DUF8574)","pfam_id":"PF26506","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8574","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26506"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26506.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"04e0a4830127e163804d9915d7f110ad288cc8960b721347aef3392bfe6bb931"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF26506","short_name":"DUF8574","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}
