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The proteins are predominantly found in the order Sulfolobales, which includes genera such as Acidianus, Metallosphaera, and Sulfolobus. The domain is approximately 110 amino acids in length. The reviewed protein SSO0428 from Saccharolobus solfataricus is a representative member of this family. Proteins in this family are predicted to form a single long alpha helix. Structure prediction suggests that this protein does not form a homomeric coiled-coil complex. Based on genomic context this protein may be an accessory subunit of the V-type ATP synthase complex.","id":"Pfam:PF26552","interpro_id":"InterPro:IPR058494","name":"Family of unknown function (DUF8181)","pfam_id":"PF26552","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8181","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26552"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26552.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0535c88b4311d199b09aa558c3167ca5c5c3bfaf8a1f22339eba3fe19afd66d2"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf8181-pf26552.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26552","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf8181-pf26552.yaml"}],"pfam_ids":["PF26552"],"protein_name":"Uncharacterized protein SSO0428","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MMSEVKFNAYSKAIMEFEDEIKRIKKEIADDSKRLITLSDSYLSELRATAEKSLGDVQKLLNDEKKRQLDEIRNKYISEREKQLEEIRKEAEKNIDKVVNEVIRQLLGVFK","sequence_length":111,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"be7c443cbebd61ed1a78e9ec5412eccdebe7939b2d813398faccaf4f5ee32e91","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9Y8K9.json","taxon_id":"273057","uniprot_accession":"Q9Y8K9","uniprot_release":"2026_03"}],"pfam_id":"PF26552","short_name":"DUF8181","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}