{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/cell-cortex-region-go0099738.yaml","source_record_id":"GO:0099738","source_record_label":"cell cortex region","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/cell-cortex-region-go0099738.yaml","source_record_id":"GO:0099738","source_record_label":"cell cortex region","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml","source_record_id":"GO:0120103","source_record_label":"centriolar subdistal appendage","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml","source_record_id":"GO:0120103","source_record_label":"centriolar subdistal appendage","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/cytoplasmic-dynein-complex-go0005868.yaml","source_record_id":"GO:0005868","source_record_label":"cytoplasmic dynein complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/dynein-complex-go0030286.yaml","source_record_id":"GO:0030286","source_record_label":"dynein complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/perinuclear-theca-go0033011.yaml","source_record_id":"GO:0033011","source_record_label":"perinuclear theca","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/retromer-complex-go0030904.yaml","source_record_id":"GO:0030904","source_record_label":"retromer complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/sterol-sensor-activity-go0032935.yaml","source_record_id":"GO:0032935","source_record_label":"sterol sensor activity","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml","source_record_id":"GO:0010457","source_record_label":"centriole-centriole cohesion","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml","source_record_id":"GO:0010457","source_record_label":"centriole-centriole cohesion","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml","source_record_id":"GO:0090120","source_record_label":"lysosome to ER cholesterol transport","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml","source_record_id":"GO:0090120","source_record_label":"lysosome to ER cholesterol transport","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/maintenance-of-synapse-structure-go0099558.yaml","source_record_id":"GO:0099558","source_record_label":"maintenance of synapse structure","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml","source_record_id":"GO:0007077","source_record_label":"mitotic nuclear membrane disassembly","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml","source_record_id":"GO:0007077","source_record_label":"mitotic nuclear membrane disassembly","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/nuclear-membrane-disassembly-go0051081.yaml","source_record_id":"GO:0051081","source_record_label":"nuclear membrane disassembly","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml","source_record_id":"GO:0090063","source_record_label":"positive regulation of microtubule nucleation","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml","source_record_id":"GO:0090063","source_record_label":"positive regulation of microtubule nucleation","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml","source_record_id":"GO:1904398","source_record_label":"positive regulation of neuromuscular junction development","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml","source_record_id":"GO:1904398","source_record_label":"positive regulation of neuromuscular junction development","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml","source_record_id":"GO:0021517","source_record_label":"ventral spinal cord development","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml","source_record_id":"GO:0021517","source_record_label":"ventral spinal cord development","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml","source_record_id":"InterPro:IPR000938","source_record_label":"CAP Gly-rich domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml","source_record_id":"InterPro:IPR000938","source_record_label":"CAP Gly-rich domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml","source_record_id":"InterPro:IPR059265","source_record_label":"Dynactin subunit 1, DUF8221","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml","source_record_id":"InterPro:IPR059265","source_record_label":"Dynactin subunit 1, DUF8221","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26666","protein_label":"","reviewed":null,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml","source_record_id":"InterPro:IPR059265","source_record_label":"Dynactin subunit 1, DUF8221","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml","source_record_id":"InterPro:IPR022157","source_record_label":"Dynein associated protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml","source_record_id":"InterPro:IPR022157","source_record_label":"Dynein associated protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","source_record_id":"Pfam:PF26666","source_record_label":"Domain of unknown function (DUF8221)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","source_record_id":"Pfam:PF26666","source_record_label":"Domain of unknown function (DUF8221)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"P28023","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","source_record_id":"Pfam:PF26666","source_record_label":"Domain of unknown function (DUF8221)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26666","protein_label":"","reviewed":null,"short_name":"DUF8221","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","source_record_id":"Pfam:PF26666","source_record_label":"Domain of unknown function (DUF8221)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/dynactin-pf12455.yaml","source_record_id":"Pfam:PF12455","source_record_label":"Dynein associated protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/dynactin-pf12455.yaml","source_record_id":"Pfam:PF12455","source_record_label":"Dynein associated protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/homologous_superfamily/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml","source_record_id":"InterPro:IPR036859","source_record_label":"CAP Gly-rich domain superfamily","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/homologous_superfamily/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml","source_record_id":"InterPro:IPR036859","source_record_label":"CAP Gly-rich domain superfamily","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/profile","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/profile/cap-gly-2.yaml","source_record_id":"PROSITE:PS50245","source_record_label":"CAP-Gly domain profile","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"sequence/profile","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/profile/cap-gly-2.yaml","source_record_id":"PROSITE:PS50245","source_record_label":"CAP-Gly domain profile","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml","source_record_id":"CATH:2.30.30.190","source_record_label":"CAP Gly-rich-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"O08788","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26666","protein_label":"Dynactin subunit 1","reviewed":true,"short_name":"DUF8221","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml","source_record_id":"CATH:2.30.30.190","source_record_label":"CAP Gly-rich-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q14203","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":2326,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":23},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a long alpha helical region found in dynactin-like proteins from eukaryotes. This region may mediate oligomerisation forming a coiled-coil.","domain_architectures":49,"interpro_id":"IPR059265","known_evidence_count":null,"matches":4049,"name":"Domain of unknown function (DUF8221)","partial_evidence_count":null,"pfam_id":"PF26666","proteins":4048,"proteomes":1798,"short_name":"DUF8221","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26666","structures":19,"taxa":4724,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF26666.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2326,"domain_architectures":49,"matches":4049,"proteins":4048,"proteomes":1798,"structures":19,"taxa":4724},"curation_status":"SEEDED","description":"This entry represents a long alpha helical region found in dynactin-like proteins from eukaryotes. This region may mediate oligomerisation forming a coiled-coil.","id":"Pfam:PF26666","interpro_id":"InterPro:IPR059265","name":"Domain of unknown function (DUF8221)","pfam_id":"PF26666","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8221","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26666"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26666.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"ea2dd041ac8ad60e1ae101d6df052edb85facf288d4ac32fe402dad229fa947a"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/cell-cortex-region-go0099738.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099738","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/cell-cortex-region-go0099738.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0120103","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/cytoplasmic-dynein-complex-go0005868.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0005868","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/cytoplasmic-dynein-complex-go0005868.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/perinuclear-theca-go0033011.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0033011","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/perinuclear-theca-go0033011.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/retromer-complex-go0030904.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0030904","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/retromer-complex-go0030904.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/sterol-sensor-activity-go0032935.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032935","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/sterol-sensor-activity-go0032935.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010457","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090120","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/nuclear-membrane-disassembly-go0051081.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051081","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/nuclear-membrane-disassembly-go0051081.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090063","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904398","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0021517","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000938","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR059265","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR022157","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26666","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8221-pf26666.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dynactin-pf12455.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF12455","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dynactin-pf12455.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR036859","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/cap-gly-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS50245","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/cap-gly-2.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.30.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O08788","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01302","PF12455","PF26666"],"protein_name":"Dynactin subunit 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"3292e6c1c6ba2870de5f7eb01884d12d15567b89315b9b34f3bbf37644cdb352","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAQSRRHMSSRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHSRLIS","sequence_length":1281,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"3292e6c1c6ba2870de5f7eb01884d12d15567b89315b9b34f3bbf37644cdb352","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/O08788.json","taxon_id":"10090","uniprot_accession":"O08788","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26666","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8221-pf26666.yaml"}],"pfam_ids":["PF01302","PF12455","PF26666"],"protein_name":"Dynactin subunit 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQSKRHMYNRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKILKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRDQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEAKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEESTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCSILISTMNKLATAMQEGEYDAERPPSKPPPVEPWPAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKTELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGGTPGQAPGALPGPGPVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKFSLPPHEGPGGNLLSGALYRKTSQLLEKLNQLSTYTHVVDITRSSPACKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHGRLIS","sequence_length":1280,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1a2fde8df23bbc665380f7600c5fa85fe4817be54b60f5dfd03c8bfa6db4dba3","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P28023.json","taxon_id":"10116","uniprot_accession":"P28023","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/cell-cortex-region-go0099738.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099738","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/cell-cortex-region-go0099738.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0120103","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/centriolar-subdistal-appendage-go0120103.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/dynein-complex-go0030286.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0030286","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/dynein-complex-go0030286.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010457","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/centriole-centriole-cohesion-go0010457.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090120","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/lysosome-to-er-cholesterol-transport-go0090120.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/maintenance-of-synapse-structure-go0099558.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099558","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/maintenance-of-synapse-structure-go0099558.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/mitotic-nuclear-membrane-disassembly-go0007077.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090063","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-microtubule-nucleation-go0090063.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904398","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-neuromuscular-junction-development-go1904398.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0021517","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/ventral-spinal-cord-development-go0021517.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000938","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cap-gly-rich-domain-ipr000938.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR059265","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/dynactin-subunit-1-duf8221-ipr059265.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR022157","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/dynein-associated-protein-ipr022157.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8221-pf26666.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26666","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8221-pf26666.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/dynactin-pf12455.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF12455","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/dynactin-pf12455.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR036859","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/cap-gly-rich-domain-superfamily-ipr036859.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/profile/cap-gly-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS50245","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/profile/cap-gly-2.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.30.190","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/cap-gly-rich-like-domain-2-30-30-190.yaml"}],"pfam_ids":["PF01302","PF12455","PF26666"],"protein_name":"Dynactin subunit 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS","sequence_length":1278,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9b6997b252fe1488a5a3413b36c55cd988be552e1f94b80edfc967106f70bdbe","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q14203.json","taxon_id":"9606","uniprot_accession":"Q14203","uniprot_release":"2026_03"}],"pfam_id":"PF26666","short_name":"DUF8221","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}