{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26739","protein_label":"","reviewed":null,"short_name":"DUF8245","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8245-ipr059289.yaml","source_record_id":"InterPro:IPR059289","source_record_label":"Domain of unknown function DUF8245","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF26739","protein_label":"Zorya protein ZorE","reviewed":true,"short_name":"DUF8245","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8245-pf26739.yaml","source_record_id":"Pfam:PF26739","source_record_label":"Domain of unknown function (DUF8245)","source_section":"canonical_examples","taxon_id":"NCBITaxon:481805","taxon_label":"Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)","uniprot_accession":"P0DW03","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF26739","protein_label":"","reviewed":null,"short_name":"DUF8245","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8245-pf26739.yaml","source_record_id":"Pfam:PF26739","source_record_label":"Domain of unknown function (DUF8245)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":136,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in uncharacterised proteins from gram-negative bacteria. It contains highly conserved histidine and three cysteine residues arranged in HCCC pattern. These residues are predicted to be located in proximity and likely to coordinate a metal ion. This domain is usually found preceding HNH nuclease domain.","domain_architectures":3,"interpro_id":"IPR059289","known_evidence_count":null,"matches":218,"name":"Domain of unknown function (DUF8245)","partial_evidence_count":null,"pfam_id":"PF26739","proteins":218,"proteomes":214,"short_name":"DUF8245","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26739","structures":0,"taxa":517,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF26739.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":136,"domain_architectures":3,"matches":218,"proteins":218,"proteomes":214,"structures":0,"taxa":517},"curation_status":"SEEDED","description":"This domain is found in uncharacterised proteins from gram-negative bacteria. It contains highly conserved histidine and three cysteine residues arranged in HCCC pattern. These residues are predicted to be located in proximity and likely to coordinate a metal ion. This domain is usually found preceding HNH nuclease domain.","id":"Pfam:PF26739","interpro_id":"InterPro:IPR059289","name":"Domain of unknown function (DUF8245)","pfam_id":"PF26739","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8245","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF26739"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF26739.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c3212e1a5f7d7fc093858cbb49b6ff2583cccf19ae3a83f6f5812ebf2bdda7ff"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8245-pf26739.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF26739","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8245-pf26739.yaml"}],"pfam_ids":["PF26739"],"protein_name":"Zorya protein ZorE","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKLSIDISELIQLGKKMLPEGVDFFLDESPIDFDPIDIELSTGKEVSIEDLDPGSGLISYHGRQVLLYIRDHSGRYDAAIVDGEKGKRFHIAWCRTLDEMRHKNRFERYHATNRIDGLFEIDDGSGRSQDVDLRVCMNCLERLNYKGSIDKQRKREIFKSFSLNEFFSDYSTCFRHMPKGIYDKTNSGYVENWKEISKEIREKANYVCNDCGVNLSTAKNLCHVHHKNGIKYDNHHENLLVLCKDCHRKQPLHEGIFVTQAEMAIIQRLRSQQGLLKAESWNEIYDLTDPSVHGDINMMQHKGFQPPVPGLDLQNSEHEIIATVEAAWPGLKIAVNLTPAEVEGWRIYTVGELVKEIQTGAFTPAKL","sequence_length":367,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"15defa2ab8a5c5af33571526a9a21b1668cd8e1ef80cccabda6daf6b7bd94a58","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0DW03.json","taxon_id":"481805","uniprot_accession":"P0DW03","uniprot_release":"2026_03"}],"pfam_id":"PF26739","short_name":"DUF8245","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}