{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF30221","protein_label":"","reviewed":null,"short_name":"DUF8614","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/nudix-hydrolase-3-dppiii-like-peptidase-domain-ipr061675.yaml","source_record_id":"InterPro:IPR061675","source_record_label":"Nudix hydrolase 3/DPPIII-like, peptidase domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF30221","protein_label":"","reviewed":null,"short_name":"DUF8614","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8614-pf30221.yaml","source_record_id":"Pfam:PF30221","source_record_label":"Domain of unknown function (DUF8614)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1004,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain of unknown function found in bacterial proteins. The function of this domain remains to be determined. The predicted structure shows strong similarity to dipeptidyl peptidase III. This suggests proteins of this family are likely to be peptidase enzymes.","domain_architectures":13,"interpro_id":"IPR061675","known_evidence_count":null,"matches":1483,"name":"Domain of unknown function (DUF8614)","partial_evidence_count":null,"pfam_id":"PF30221","proteins":1483,"proteomes":1278,"short_name":"DUF8614","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF30221","structures":2,"taxa":2481,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF30221.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1004,"domain_architectures":13,"matches":1483,"proteins":1483,"proteomes":1278,"structures":2,"taxa":2481},"curation_status":"SEEDED","description":"This entry represents a domain of unknown function found in bacterial proteins. The function of this domain remains to be determined. The predicted structure shows strong similarity to dipeptidyl peptidase III. This suggests proteins of this family are likely to be peptidase enzymes.","id":"Pfam:PF30221","interpro_id":"InterPro:IPR061675","name":"Domain of unknown function (DUF8614)","pfam_id":"PF30221","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8614","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF30221"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF30221.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b604f6fe2aefa91fce63fe135a1418cb473c9d89693b01bfe66d7f79eaeb5c86"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8614-pf30221.yaml","qualification_status":"QUALIFIED","record_id":"Pfam:PF30221","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8614-pf30221.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q8L831","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00293","PF30221"],"protein_name":"Nudix hydrolase 3","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"b5f60c8080a3c39b4f92c2f224c46a27887fca021351eae675ef609752891665","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAEEHFDVLTKSGEKTGVSKPRGEVHRDGDYHRAVHVWIFVETTQQLLLQLRSDDKDSWPGQWDISSAGHISAGDTSLLSAQRELEEELGVKLPKDAFEKIFVFLQECVTNDGKFINNEFNDVYLVTILHPIPLEAFTLQKEEVSAVKYVPYEEYRNFLSKEDPAYVPYDVNGEYGKLFDIIRQRCQVNTEARSLSLQKQLQRYSPVTLEAKLTELSEADQKALGLIVKAAKIMDDIFYEQVWNSNPALRDWLKDHANASKLDKLKWDYFTINKSPWSSLDENEAFLSTADSAVKLLPGATKAIAGWKGLEYRAAFPVTKPPGANFYPPDMDKMEFTLWLNGLTEEQKHAATGFFSVIKRRSEANLDASDHLASSTKKLPDSNSDLYSIPYSEIYRPFLKKASEFLQKAGDLVSSPSLKKLLHSKAEAFLSNEYYESDIAWMDLDSKLDITIGPYETYEDEIFGYKATFETFIGIRDDKATADLKLFGDNLKLLEDNLPLESVYKSTDVSAAPIRVIQLIYNSGDVKGPQTVAYNLPNDEKIVKDRGTSMVMLKNVQEAKFEHILKPIAEITISKEQRGLVDFDSFFTHTICHECCHGIGPHTITLPGGQTSTVRKELQEVHSAMEEAKADIVGLWALKFLITKGLLSKSMVESMYVSFLAGCFRSIRFGLTEAHGKGQALQFNYLYEKGAFVFHEDSTFSVDFAKIEGAVESLSHEILTIQGKGDKNAATLLLNKYCTITGPLKTALENLERVKVPVDISPTFPLAEALMN","sequence_length":772,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"b5f60c8080a3c39b4f92c2f224c46a27887fca021351eae675ef609752891665","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8L831.json","taxon_id":"3702","uniprot_accession":"Q8L831","uniprot_release":"2026_03"}],"pfam_id":"PF30221","short_name":"DUF8614","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
