{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF31066","protein_label":"","reviewed":null,"short_name":"DUF8799","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf8799-ipr061860.yaml","source_record_id":"InterPro:IPR061860","source_record_label":"Domain of unknown function DUF8799","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF31066","protein_label":"","reviewed":null,"short_name":"DUF8799","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf8799-pf31066.yaml","source_record_id":"Pfam:PF31066","source_record_label":"Domain of unknown function (DUF8799)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1103,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain of approximately 70 residues found in BPTF (Bromodomain PHD finger transcription factor) proteins and related DDT domain-containing proteins in eukaryotes. This domain is located downstream of the WSD domain ([pfam:PF15613]). BPTF is a subunit of the NURF chromatin remodelling complex that catalyses ATP-dependent nucleosome sliding [[cite:PUB00101089]]. In plant RLT (RINGLET) proteins, this domain is also present downstream of the WSD domain. The function of this domain remains to be determined.","domain_architectures":200,"interpro_id":"IPR061860","known_evidence_count":null,"matches":5604,"name":"Domain of unknown function (DUF8799)","partial_evidence_count":null,"pfam_id":"PF31066","proteins":5603,"proteomes":1563,"short_name":"DUF8799","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF31066","structures":0,"taxa":4976,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF31066.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1103,"domain_architectures":200,"matches":5604,"proteins":5603,"proteomes":1563,"structures":0,"taxa":4976},"curation_status":"SEEDED","description":"This entry represents a domain of approximately 70 residues found in BPTF (Bromodomain PHD finger transcription factor) proteins and related DDT domain-containing proteins in eukaryotes. This domain is located downstream of the WSD domain ([pfam:PF15613]). BPTF is a subunit of the NURF chromatin remodelling complex that catalyses ATP-dependent nucleosome sliding [[cite:PUB00101089]]. In plant RLT (RINGLET) proteins, this domain is also present downstream of the WSD domain. The function of this domain remains to be determined.","id":"Pfam:PF31066","interpro_id":"InterPro:IPR061860","name":"Domain of unknown function (DUF8799)","pfam_id":"PF31066","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF8799","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF31066"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF31066.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a1cf59180b881114463c0041b43dfd6699d790838fc8936323191478df06292f"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:F4HY56","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00046","PF02791","PF05066","PF15612","PF15613","PF31066"],"protein_name":"Homeobox-DDT domain protein RLT1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"50e9992177d4c9234aa76e244405c0caf765a9797be675bd1b1fc77ee33c5bf4","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MEMGSDGEDQKIRSVVGDANLNNKKKKIDNNSSSKDGRVKPKRQMKTPFQLETLEKVYSEEKYPSEATRAELSEKLDLSDRQLQMWFCHRRLKDKKDGQSNKPVKSSVAAVQSASVNELPAAAGSVPEQDSRSDSGSESGCSPYSNSRRNFASGSSSSRAELDEYETMGKPSYESRLSTMVHRAIVCIEAQLGEPLRDDGPILGMEFDPLPPGAFGTPIAMQKHLLHPYESDLYERHDPRPRRSHAAARSFHEQQSLDDPSSFTPNMYERYSENHARGMDYEVARSRISSFMHANGPVPRSYVTPGHASRNCSTSQQDMPSPIESAHHGDRFLLEKDSSVLGTEDPYLLPDGVRKSSDVHRKGKINDGRLGRGSETRENHGPKDLEKLEIQRKKNEERMRKEMERNERERRKEEERLMRERIKEEERLQREQRREVERREKFLQRENERAEKKKQKDEIRREKDAIRRKLAIEKATARRIAKESMDLIEDEQLELMELAAISKGLPSVLQLDHDTLQNLEVYRDSLSTFPPKSLQLKMPFAISPWKDSDETVGNLLMVWRFLISFSDVLDLWPFTLDEFIQAFHDYDSRLLGEIHVTLLRSIIRDVEDVARTPFSGIGNNQYTTANPEGGHPQIVEGAYAWGFDIRSWKKHLNPLTWPEILRQLALSAGFGPKLKKKHSRLTNTGDKDEAKGCEDVISTIRNGTAAESAFASMREKGLLAPRKSRHRLTPGTVKFAAFHVLSLEGSKGLTVLELADKIQKSGLRDLTTSKTPEASISVALTRDVKLFERIAPSTYCVRAPYVKDPKDGEAILADARKKIRAFENGFTGPEDVNDLERDEDFEIDIDEDPEVDDLATLASASKSAVLGEANVLSGKGVDTMFCDVKADVKSELEKEFSSPPPSTMKSIVPQHSERHKNTVVGGVDAVIDESNQGQSWIQGLTEGDYCHLSVEERLNALVALVGIANEGNSIRTGLEDRMEAANALKKQMWAEAQLDNSCMRDVLKLDLQNLASSKTESTIGLPIIQSSTRERDSFDRDPSQLLDETKPLEDLSNDLHKSSAERALINQDANISQENYASKRSRSQLKSYIGHKAEEVYPYRSLPLGQDRRHNRYWHFAVSVSKSDPCSRLLFVELHDGKWLLIDSEEAFDILVASLDMRGIRESHLRIMLQKIEGSFKENACKDIKLARNPFLTEKSVVNHSPTDSVSPSSSAISGSNSDSMETSTSIRVDLGRNDTENKNLSKRFHDFQRWMWTETYSSLPSCARKYGKKRSELLATCDACVASYLSEYTFCSSCHQRLDVVDSSEILDSGLAVSPLPFGVRLLKPLLVFLEASVPDEALESFWTEDQRKKWGFRLNTSSSPGELLQVLTSLESAIKKESLSSNFMSAKELLGAANAEADDQGSVDVLPWIPKTVSAVALRLSELDASIIYVKPEKPEVIPEDENEQISLFPRDSPFKGKGPREQEDQDEVAPNPGNRNKKRARVSLGSGSNRKVKRKKAQSGLNKFVVGRRNVAVNSNLMAVELNHQVPGKGKRTVRKRPERIDEDNSHLVNRMANIVRPKSEEVEEDEEEEEQTFRDINEDWAAGETPREMEEDWANETPNRMMTPMQVDDESDNSVGVESEDEDGGGQFVDYSQRNKWGLDWNSNLNVAIEEDEEEEVVGVGRVEGEDDAEMSESSEDDDVPANNAANNYDRESEGYSSSDS","sequence_length":1705,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"50e9992177d4c9234aa76e244405c0caf765a9797be675bd1b1fc77ee33c5bf4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/F4HY56.json","taxon_id":"3702","uniprot_accession":"F4HY56","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf8799-pf31066.yaml","qualification_status":"QUALIFIED","record_id":"Pfam:PF31066","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf8799-pf31066.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q12830","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00439","PF00628","PF02791","PF15613","PF31066"],"protein_name":"Nucleosome-remodeling factor subunit BPTF","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"82ec05b1efebbb57e2fa85b1df3929956cbcfb81c8156a44d6f202872bbb0000","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAPGRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQSESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAS","sequence_length":3046,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"82ec05b1efebbb57e2fa85b1df3929956cbcfb81c8156a44d6f202872bbb0000","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q12830.json","taxon_id":"9606","uniprot_accession":"Q12830","uniprot_release":"2026_03"}],"pfam_id":"PF31066","short_name":"DUF8799","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}