id: Pfam:PF00563
pfam_id: PF00563
name: EAL domain
short_name: EAL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00563
counters:
  proteins: 131837
  matches: 131993
  proteomes: 12530
  taxa: 17849
  structures: 75
  alphafold_models: 78574
  domain_architectures: 3876
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001633
description: This domain is found in diverse bacterial signaling proteins. It is called EAL after its
  conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function
  [[cite:PUB00007150]]. The domain contains many conserved acidic residues that could participate in metal
  binding and might form the phosphodiesterase active site [[cite:PUB00007150]].