id: Pfam:PF00668
pfam_id: PF00668
name: Condensation domain
short_name: Condensation
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00668
counters:
  proteins: 68562
  matches: 149357
  proteomes: 8647
  taxa: 14069
  structures: 107
  alphafold_models: 14105
  domain_architectures: 7481
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001242
description: This domain is found in many multi-domain enzymes which synthesise peptide antibiotics. This
  domain catalyses a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis.
  It is usually found to the carboxy side of a phosphopantetheine binding domain ([pfam:PF00550]). It
  has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active
  site [[cite:PUB00007135]].