id: Pfam:PF00902
pfam_id: PF00902
name: Sec-independent protein translocase protein (TatC)
short_name: TatC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00902
counters:
  proteins: 18890
  matches: 19252
  proteomes: 16293
  taxa: 23768
  structures: 11
  alphafold_models: 12534
  domain_architectures: 28
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002033
description: 'The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme
  complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta
  pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway
  requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein
  is essential for the function of both pathways. It might be involved in twin-arginine signal peptide
  recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains
  six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC
  are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first
  cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least
  two TatC molecules co-exist within each Tat translocon [[cite:PUB00011123]].'