id: Pfam:PF00924
pfam_id: PF00924
name: Mechanosensitive ion channel, beta-domain
short_name: MS_channel_2nd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF00924
counters:
  proteins: 69957
  matches: 69995
  proteomes: 20063
  taxa: 30243
  structures: 65
  alphafold_models: 46372
  domain_architectures: 274
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006685
description: This entry includes small conductance mechanosensitive channels (MscS), which assembles to
  a homoheptameric complex [[cite:PUB00019883],[cite:PUB00019884],[cite:PUB00019885],[cite:PUB00101036],[cite:PUB00062568],[cite:PUB00101037]].
  Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed
  of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain
  [[cite:PUB00101036],[cite:PUB00062568],[cite:PUB00101037],[cite:PUB00064132]]. This is the beta domain
  which adopts a Sm-like barrel structure.