id: Pfam:PF01060
pfam_id: PF01060
name: Transthyretin-like family
short_name: TTR-52
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01060
counters:
  proteins: 4864
  matches: 5108
  proteomes: 114
  taxa: 297
  structures: 1
  alphafold_models: 4620
  domain_architectures: 133
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001534
description: TTR-52 was called family 2 in [[cite:PUB00001984]], and has weak similarity to transthyretin
  (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein
  is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking
  surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane
  receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure [[cite:PUB00109168]].