id: Pfam:PF01169
pfam_id: PF01169
name: Divalent cation/proton antiporter GDT1
short_name: GDT1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01169
counters:
  proteins: 13378
  matches: 25173
  proteomes: 9440
  taxa: 17433
  structures: 0
  alphafold_models: 9762
  domain_architectures: 121
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001727
description: This entry, previously known as UPF0016, represents the budding yeast Divalent cation/proton
  antiporter GDT1 and its homologue, the human TMEM165 that are functionally related and form a new group
  of Golgi-localised cation/Ca(2+) exchangers. Budding yeast GDT1 is a Golgi-localised calcium transporter
  required for stress-induced calcium signalling and protein glycosylation [[cite:PUB00079030]]. TMEM165,
  also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation
  in cells [[cite:PUB00079031],[cite:PUB00152812]]. Most members of the family contain two copies of a
  region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.