id: Pfam:PF01205
pfam_id: PF01205
name: Impact N-terminal domain
short_name: Impact_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01205
counters:
  proteins: 18592
  matches: 18629
  proteomes: 16361
  taxa: 26223
  structures: 5
  alphafold_models: 12878
  domain_architectures: 121
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001498
description: This entry represents the N-terminal domain of the Impact proteins. The Impact protein is
  a translational regulator that ensures constant high levels of translation under amino acid starvation.
  It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1
  to 4) and subsequent down-regulation of protein synthesis [[cite:PUB00161305],[cite:PUB00158485]]. It
  is evolutionary conserved from eukaryotes to archaea [[cite:PUB00046141]].