id: Pfam:PF01458
pfam_id: PF01458
name: SUF system FeS cluster assembly, SufBD core domain
short_name: SUFBD_core
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01458
counters:
  proteins: 30443
  matches: 30502
  proteomes: 15015
  taxa: 22322
  structures: 8
  alphafold_models: 20235
  domain_architectures: 56
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR000825
description: 'Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron
  transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These
  functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S]
  [[cite:PUB00035635]]. FeS cluster assembly is a complex process involving the mobilisation of Fe and
  S atoms from storage sources, their assembly into [Fe-S] form, their transport to specific cellular
  locations, and their transfer to recipient apoproteins. So far, three FeS assembly machineries have
  been identified, which are capable of synthesising all types of [Fe-S] clusters: ISC (iron-sulphur cluster),
  SUF (sulphur assimilation), and NIF (nitrogen fixation) systems. The SUF system is an alternative pathway
  to the ISC system that operates under iron starvation and oxidative stress. It is found in eubacteria,
  archaea and eukaryotes (plastids). The SUF system is encoded by the suf operon (sufABCDSE), and the
  six encoded proteins are arranged into two complexes (SufSE and SufBCD) and one protein (SufA). SufS
  is a pyridoxal-phosphate (PLP) protein displaying cysteine desulphurase activity. SufE acts as a scaffold
  protein that accepts S from SufS and donates it to SufA [[cite:PUB00035639]]. SufC is an ATPase with
  an unorthodox ATP-binding cassette (ABC)-like component. SufA is homologous to IscA [[cite:PUB00035640]],
  acting as a scaffold protein in which Fe and S atoms are assembled into [FeS] cluster forms, which can
  then easily be transferred to apoproteins targets. This entry represents the core domain of SufB and
  SufD proteins, which are homologous, and form part of the SufBCD complex in the SUF system [[cite:PUB00089444]].
  SufB accepts sulfur transferred from SufE [[cite:PUB00089442]], whereas SufD may play a role in iron
  acquisition [[cite:PUB00089443]].'