id: Pfam:PF01594
pfam_id: PF01594
name: AI-2E family transporter
short_name: AI-2E_transport
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01594
counters:
  proteins: 58169
  matches: 58317
  proteomes: 19308
  taxa: 29447
  structures: 2
  alphafold_models: 37191
  domain_architectures: 79
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002549
description: This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA,
  has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear
  if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration
  of AI-2, TqsA affects gene expression in biofilms and biofilm formation [[cite:PUB00076990]]. TsqA belongs
  to the AI-2 exporter (AI-2E) superfamily [[cite:PUB00076989]].