id: Pfam:PF01679
pfam_id: PF01679
name: Proteolipid membrane potential modulator
short_name: Pmp3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01679
counters:
  proteins: 12165
  matches: 12229
  proteomes: 5976
  taxa: 10614
  structures: 2
  alphafold_models: 9376
  domain_architectures: 139
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR000612
description: Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe,
  is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway.
  It functions to modulate the membrane potential, particularly to resist high cellular cation concentration.
  In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting
  environmental signals that will regulate gene expression for allowing the cell to adapt to cellular
  stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.