id: Pfam:PF01732
pfam_id: PF01732
name: Mycoplasma immunoglobulin protease
short_name: Myco_protease
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01732
counters:
  proteins: 480
  matches: 483
  proteomes: 120
  taxa: 185
  structures: 1
  alphafold_models: 346
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022382
description: This is the serine protease domain of MIP (Mycoplasma immunoglobulin protease), a protein
  that is related to pathogenicity of animal and human pathogenic Mycoplasmas [[cite:PUB00098027],[cite:PUB00098028],[cite:PUB00098029],[cite:PUB00151017]].
  This protein functions together with the Ig binding protein M (MIB) to evade host Ig-mediated defense
  against the MIB-MIP system, which is a novel mechanism that protects mycoplasma against host immune
  response [[cite:PUB00098028],[cite:PUB00151017]]. MIB tightly interacts to the antigen-binding fragment
  (Fab) and recruits the MIP protease that is activated and cleaves the IgG heavy chain, disrupting the
  antigen binding site. Therefore, the MIB-MIP system appears to be crucial to mycoplasma immune evasion
  [[cite:PUB00151017]].