id: Pfam:PF01757
pfam_id: PF01757
name: Acyltransferase domain
short_name: Acyl_transf_3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01757
counters:
  proteins: 79491
  matches: 80016
  proteomes: 17243
  taxa: 26410
  structures: 0
  alphafold_models: 51499
  domain_architectures: 429
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002656
description: This family includes a range of acyltransferase enzymes. This domain is found in a wide range
  of acyltransferase enzymes, including, mainly, bacterial proteins which catalyse the transfer of acyl
  groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C
  (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral
  membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl
  residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification
  that determines lysozyme resistance [[cite:PUB00097284],[cite:PUB00097283]]. This domain is also present
  in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator
  of hypoxia-inducible factor 1) [[cite:PUB00097285]] and NRF6 (Nose resistant to fluoxetine protein 6)
  from Caenorhabditis elegans [[cite:PUB00097286]].