id: Pfam:PF01784
pfam_id: PF01784
name: Duf34/NIF3 (NGG1p interacting factor 3)
short_name: DUF34_NIF3
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01784
counters:
  proteins: 18574
  matches: 18654
  proteomes: 16807
  taxa: 26806
  structures: 16
  alphafold_models: 12676
  domain_architectures: 53
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002678
description: This family includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed
  across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 [[cite:PUB00070175]]
  and, recently, through a comprehensive literature review and integrative bioinformatics analyses it
  was revealed that annotations for these members were misleading as they were based on a single set of
  in vitro results examining the NIF3 homolog of Helicobacter pylori [[cite:PUB00070175]]. Actually, they
  have varied phenotypes with the unifying functional role as metal-binding proteins [[cite:PUB00100327]].
  This entry contains several NIF3 (NGG1p interacting factor 3) protein homologues. NIF3 interacts with
  the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of
  this interaction is unknown [[cite:PUB00002954],[cite:PUB00019927]].