id: Pfam:PF01809
pfam_id: PF01809
name: Putative membrane protein insertion efficiency factor
short_name: YidD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01809
counters:
  proteins: 17388
  matches: 17388
  proteomes: 16077
  taxa: 23500
  structures: 0
  alphafold_models: 11202
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002696
description: This family consists of membrane insertion efficiency factor proteins. They contain three
  conserved cysteine residues. Family members such as YidD may be involved in insertion of integral membrane
  proteins into the membrane by assisting YidC (membrane protein insertase). Some members of the yidD
  family have been previously thought to posses alpha-hemolysin activity, however no sufficient evidence
  was found to corroborate this idea. Secondary structure prediction indicated the presence of three alpha-helices
  in YidD. None of the three alpha-helices appeared sufficiently hydrophobic to serve as a transmembrane,
  suggesting a cytoplasmic localization for YidD. However, a closer examination of the alpha-helical wheel
  projection of the predicted first alpha-helix in YidD suggested an amphipathic structure in its N-terminal
  region which might be involved in membrane targeting [[cite:PUB00064882]].