id: Pfam:PF01863
pfam_id: PF01863
name: YgjP-like, metallopeptidase domain
short_name: YgjP-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01863
counters:
  proteins: 15247
  matches: 15593
  proteomes: 12259
  taxa: 17503
  structures: 2
  alphafold_models: 9610
  domain_architectures: 18
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002725
description: This is a conserved domain containing the catalytic zinc-metallopeptidase (HExxH) catalytic
  motif. Proteins containing this domain are found in some archaebacteria, as well as Helicobacter pylori.
  The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing
  three conserved histidines [[cite:PUB00098014],[cite:PUB00098016],[cite:PUB00098015],[cite:PUB00084997]].
  This domain is found in YgjP from E. coli [[cite:PUB00084997]], a predicted metal-dependent hydrolase
  that hydrolyses UTP to UMP and diphosphate in vitro; and in MJ0123 from Methanocaldococcus jannaschii
  (also referred to as projannalysin) [[cite:PUB00098015]].