id: Pfam:PF01885
pfam_id: PF01885
name: RNA 2'-phosphotransferase, Tpt1 / KptA family
short_name: PTS_2-RNA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01885
counters:
  proteins: 8160
  matches: 8272
  proteomes: 6226
  taxa: 12585
  structures: 28
  alphafold_models: 5779
  domain_architectures: 192
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002745
description: Tpt1 catalyses the last step of tRNA splicing in yeast. It transfers the splice junction
  2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed
  to be followed by a transesterification step to release the RNA. The first step of this reaction is
  similar to that catalysed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the
  same reaction mechanism [[cite:PUB00008050]].