id: Pfam:PF01886
pfam_id: PF01886
name: Protein of unknown function DUF61
short_name: DUF61
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01886
counters:
  proteins: 196
  matches: 196
  proteomes: 193
  taxa: 381
  structures: 1
  alphafold_models: 181
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002746
description: This Domain of unknown function 61 (DUF61) family of proteins are widely distributed in archaea.
  In crenarchaea, the genes of DUF61 proteins are in an operon containing two genes of box C/D RNA protein
  complexes. The NMR structure of a DUF61 family member from the hyperthermophilic archaeon Sulfolobus
  solfataricus revealed a rigid core structure and flexible N- and C-terminal regions, including a negatively-charged
  independent C-terminal helix. The core structure consists of N- and C-terminal subdomains, in which
  the C-terminal subdomain shows significant structural similarity with several nucleic acid binding proteins
  [[cite:PUB00098020]].