id: Pfam:PF01887
pfam_id: PF01887
name: SAM hydroxide adenosyltransferase N-terminal domain
short_name: SAM_HAT_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01887
counters:
  proteins: 4611
  matches: 4632
  proteomes: 4378
  taxa: 7070
  structures: 33
  alphafold_models: 3211
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046469
description: This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria.
  The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [[cite:PUB00047427]].
  S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side
  chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [[cite:PUB00054078]].
  This family used to be known as DUF62.