id: Pfam:PF01900
pfam_id: PF01900
name: Rpp14/Pop5 family
short_name: RNase_P_Rpp14
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01900
counters:
  proteins: 5287
  matches: 5297
  proteomes: 3673
  taxa: 9445
  structures: 15
  alphafold_models: 4599
  domain_architectures: 79
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002759
description: tRNA processing enzyme ribonuclease P (RNase P) is a ubiquitous ribozyme that catalyzes a
  Mg2-dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA). Archaeal and
  eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic
  RNase P consists of 9 or 10 proteins [[cite:PUB00007201]]. Human RNase P is composed of a singular protein
  Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14- (Rpp30)2-Rpp40 heteropentamer,
  and Rpp21-Rpp29-Rpp38 heterotrimer. This family includes Rnp2 (also known as Pop5) from archaea [[cite:PUB00097410]]
  and Pop5/Rpp14 from eukaryotes [[cite:PUB00100655],[cite:PUB00097413]].