id: Pfam:PF01902
pfam_id: PF01902
name: Diphthamide synthase N-terminal domain
short_name: Diphthami_syn_2_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01902
counters:
  proteins: 6563
  matches: 6660
  proteomes: 5387
  taxa: 11776
  structures: 4
  alphafold_models: 5074
  domain_architectures: 91
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR060003
description: This entry represents the N-terminal domain of Diphthamide synthase. Diphthamide synthase
  catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase
  is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine
  residue found on archaeal and eukaryotic translation elongation factor 2 (eEF-2) [[cite:PUB00073561]].
  In some members of this family e.g. [swissprot:Q12429], this domain is associated with [pfam:PF01042].
  The enzyme classification is [ec:6.3.1.14].