id: Pfam:PF01909
pfam_id: PF01909
name: Nucleotidyltransferase domain
short_name: NTP_transf_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01909
counters:
  proteins: 24660
  matches: 24705
  proteomes: 12011
  taxa: 19472
  structures: 133
  alphafold_models: 16552
  domain_architectures: 272
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002934
description: Members of this family belong to a large family of nucleotidyltransferases [[cite:PUB00005745]].
  This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible
  for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing
  the addition of a nucleotidyl group onto the drug.