id: Pfam:PF01933
pfam_id: PF01933
name: 2-phospho-L-lactate transferase CofD
short_name: CofD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01933
counters:
  proteins: 14174
  matches: 14214
  proteomes: 10830
  taxa: 17069
  structures: 13
  alphafold_models: 9318
  domain_architectures: 45
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002882
description: This entry contains 2-phospho-L-lactate transferase (CofD), phosphoenolpyruvate transferase
  and related sequences. CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is
  the transfer of the 2-phospholactate moiety from lactyl (2)diphospho-(5') guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin
  (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl- 8-hydroxy-5-deazariboflavin
  (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other
  lineages. This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii)
  [[cite:PUB00013496]] but appears restricted to F420-containing species and is predicted to carry out
  the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form
  a Rossmann fold, and 13 alpha-helices [[cite:PUB00050875]].