id: Pfam:PF01935
pfam_id: PF01935
name: Helicase HerA, central domain
short_name: DUF87
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01935
counters:
  proteins: 11479
  matches: 11481
  proteomes: 6966
  taxa: 11524
  structures: 38
  alphafold_models: 7658
  domain_architectures: 87
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002789
description: This entry represents the central domain found in archaeal proteins such as DNA double-strand
  break repair helicase HerA ([ec:3.6.4.12]). HerA is a helicase which is able to utilise either 3' or
  5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [[cite:PUB00076694]].
  It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is
  essential for cell viability in the crenarchaeon Sulfolobus islandicus [[cite:PUB00076695]]. This domain
  includes the the central RecA-like catalytic core and a flanking four-helix bundle [[cite:PUB00078094]].
  The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines
  that could be metal ligands.