id: Pfam:PF01941
pfam_id: PF01941
name: S-adenosylmethionine synthetase (AdoMet synthetase)
short_name: AdoMet_Synthase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01941
counters:
  proteins: 974
  matches: 991
  proteomes: 897
  taxa: 1739
  structures: 12
  alphafold_models: 794
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027790
description: This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet
  synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolism
  of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a
  precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine
  synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a
  unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed.
  MATs from various organisms contain ~400-amino acid polypeptide chains [[cite:PUB00019110]].