id: Pfam:PF01947
pfam_id: PF01947
name: Chorismate pyruvate-lyase Rv2949c-like
short_name: Rv2949c-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01947
counters:
  proteins: 726
  matches: 741
  proteomes: 660
  taxa: 1609
  structures: 1
  alphafold_models: 531
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002800
description: This domain is found in chorismate pyruvate-lyases ([ec:4.1.3.40], also known as 4-HB synthase
  and p-hydroxybenzoic acid synthase) such as those found in Mycobacterium tuberculosis where it removes
  the pyruvyl group from chorismate to provide 4-hydroxybenzoate (4HB) [[cite:PUB00086017]]. The chorismate
  pyruvate-lyase encoded by sll1797 in cyanobacteria Synechocystis sp. , has been shown to catalyse the
  initial and essential step in plastoquinone biosynthesis [[cite:PUB00097745]]. In E. coli, the chorismate
  lyase (UbiC) catalyses the conversion of chorismate to p-hydroxybenzoate and pyruvate in the biosynthesis
  of ubiquinone as well [[cite:PUB00097746]].