id: Pfam:PF01949
pfam_id: PF01949
name: Endonuclease dU
short_name: Endo_dU
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01949
counters:
  proteins: 778
  matches: 778
  proteomes: 762
  taxa: 1518
  structures: 1
  alphafold_models: 660
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002802
description: This family includes Endonuclease dU from Archaeoglobus fulgidus (Endo_dU, AF_1433) and similar
  proteins mainly found in archaea. Sequence and structure analysis to identify RNase H-like superfamily
  members, has clustered this family in endonuclease Clade V, thus suggesting endonuclease activity of
  these proteins [[cite:PUB00098031]]. Endo_dU, which cleave the 3'-side of deoxyuridine (dU) on DNA substrates,
  shows a typical RNase H-like fold, with a core structure of five beta-strands and three alpha-helices.
  It may participate in DNA repair [[cite:PUB00160071]]. This family was formerly known as DUF99.