id: Pfam:PF01957
pfam_id: PF01957
name: NfeD-like C-terminal, partner-binding domain
short_name: NfeD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01957
counters:
  proteins: 15192
  matches: 15193
  proteomes: 12513
  taxa: 17949
  structures: 5
  alphafold_models: 9701
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002810
description: 'NfeD-like proteins are widely distributed throughout prokaryotes and are frequently associated
  with genes encoding stomatin-like proteins (slipins). There appear to be three major groups: an ancestral
  group with only an N-terminal serine protease domain and this C-terminal beta sheet-rich domain which
  is structurally very similar to the OB-fold domain, associated with its neighbouring slipin cluster;
  a second major group with an additional middle, membrane-spanning domain, associated in some species
  with eoslipin and in others with yqfA; a final ''artificial'' group which unites truncated forms lacking
  the protease region and associated with their ancestral gene partner, either yqfA or eoslipin. This
  NefD, C-terminal, domain appears to be the major one for relating to the associated protein. NfeD homologues
  are clearly reliant on their conserved gene neighbour which is assumed to be necessary for function,
  either through direct physical interaction or by functioning in the same pathway, possibly involve with
  lipid-rafts [[cite:PUB00064250]].'