id: Pfam:PF01959
pfam_id: PF01959
name: 3-dehydroquinate synthase II N-terminal domain
short_name: DHQS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01959
counters:
  proteins: 1847
  matches: 1855
  proteomes: 1461
  taxa: 2975
  structures: 0
  alphafold_models: 1397
  domain_architectures: 24
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR030960
description: This entry represents the N-terminal TIM barrel domain of 3-dehydroquinate synthase II. This
  family includes members of 3-dehydroquinate synthase II ([ec:1.4.1.24]), encoded by aroB genes in M.
  maripaludis which is widely distributed in methanogens. In M. jannaschii, proteins ADTH synthase (AroA)
  and DHQ synthase II (AroB) are required to convert 6-deoxy-5-ketofructose-1-phosphate (DKFP) and aspartate
  semialdehyde to 3-dehydroquinate (DHQ) in vitro [[cite:PUB00109170],[cite:PUB00060486]].