id: Pfam:PF01969
pfam_id: PF01969
name: Nickel insertion protein
short_name: Ni_insertion
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01969
counters:
  proteins: 4090
  matches: 4175
  proteomes: 3294
  taxa: 6143
  structures: 5
  alphafold_models: 2928
  domain_architectures: 19
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002822
description: Members of this family may be involved in the activation of nickel-pincer cofactor-dependent
  enzymes. LarC from Lactobacillus plantarum is involved, together with LarB and LarE, in the synthesis
  of the enzyme-bound cofactor of lactate racemase (LarA). Larc C binds Ni2+, and functions in nickel
  delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor
  [[cite:PUB00085157],[cite:PUB00086644]].