id: Pfam:PF01970
pfam_id: PF01970
name: Tripartite tricarboxylate transporter TctA family
short_name: TctA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01970
counters:
  proteins: 18234
  matches: 18244
  proteomes: 7121
  taxa: 9990
  structures: 0
  alphafold_models: 11882
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002823
description: This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate
  transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families,
  distinct from the ABC and TRAP-T families [[cite:PUB00106923]]. TctA is part of the tripartite TctABC
  system which, as characterised in S. typhimurium [[cite:PUB00106922]], is a secondary carrier that depends
  for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane
  proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large
  transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such
  in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most
  other bacteria functions without TctB and TctC molecules [[cite:PUB00106923]].