id: Pfam:PF01985
pfam_id: PF01985
name: CRS1 / YhbY (CRM) domain
short_name: CRS1_YhbY
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01985
counters:
  proteins: 15752
  matches: 23182
  proteomes: 8486
  taxa: 12703
  structures: 6
  alphafold_models: 11674
  domain_architectures: 130
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR001890
description: Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function
  in ribosome assembly. GFP fused to a single-domain CRM protein from maize localises to the nucleolus,
  suggesting that an analogous activity may have been retained in plants [[cite:PUB00043747]]. A CRM domain
  containing protein in plant chloroplasts has been shown to function in group I and II intron splicing
  [[cite:PUB00044700]]. In vitro experiments with an isolated maize CRM domain have shown it to have RNA
  binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome
  function prior to the divergence of Archaea and Bacteria, that this function has been maintained in
  extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution
  of plant genomes [[cite:PUB00043747]]. YhbY has a fold similar to that of the C-terminal domain of translation
  initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome [[cite:PUB00019352]][[cite:PUB00019353]].