id: Pfam:PF01989
pfam_id: PF01989
name: Aconitase X swivel domain
short_name: AcnX_swivel_put
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01989
counters:
  proteins: 2019
  matches: 2019
  proteomes: 1838
  taxa: 3213
  structures: 6
  alphafold_models: 1449
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002840
description: This entry represents a domain centrally found in Phosphomevalonate dehydratase small subunit
  from Aeropyrum pernix (PMDh-S) and similar prokaryotic proteins previously annotated as aconitase X
  subunit 2, the swiveling domain subunit [[cite:PUB00080857]]. PMDh-S is a component of a hydro-lyase
  that catalyses the dehydration of mevalonate 5-phosphate (MVA5P) to form trans- anhydromevalonate 5-phosphate
  (tAHMP) [[cite:PUB00098043],[cite:PUB00154971]]. It is involved in the archaea; mevalonate (MVA) pathway,
  which provides fundamental precursos for isoprenoid biosynthesis such as isopentenyl diphosphate (IPP)
  and dimenthylallyl diphosphate (DMAPP) [[cite:PUB00098043],[cite:PUB00154970]]. This domain is also
  found at the N-terminal end of Cis-3-hydroxy-L-proline dehydratase from Agrobacterium fabrum (LhpI),
  which catalyses the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta1-pyrroline-2- carboxylate
  (Pyr2C) [[cite:PUB00088769]].