id: Pfam:PF01994
pfam_id: PF01994
name: tRNA ribose 2'-O-methyltransferase, aTrm56
short_name: Trm56
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF01994
counters:
  proteins: 591
  matches: 595
  proteomes: 581
  taxa: 1062
  structures: 4
  alphafold_models: 555
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002845
description: This family is an aTrm56 that catalyses the 2'-O-methylation of the cytidine residue in archaeal
  tRNA, using S-adenosyl-L-methionine. Biochemical assays showed that aTrm56 forms a dimer and prefers
  the L-shaped tRNA to the lambda form as its substrate [[cite:PUB00046137]] [[cite:PUB00046138]]. aTrm56
  consists of the SPOUT domain, which contains the characteristic deep trefoil knot for AdoMet binding,
  and a unique C-terminal beta-hairpin [[cite:PUB00046136]].