id: Pfam:PF02006
pfam_id: PF02006
name: Phosphopantothenate/pantothenate synthetase
short_name: PPS_PS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02006
counters:
  proteins: 578
  matches: 578
  proteomes: 577
  taxa: 1045
  structures: 5
  alphafold_models: 541
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002855
description: This family of archaeal proteins includes pantothenate synthetase from Methanosarcina mazei
  and 4-phosphopantoate--beta-alanine ligase (phosphopantothenate synthetase) from Pyrococcus kodakaraensis.
  Pantothenate synthetase catalyses the condensation of pantoate with beta-alanine in an ATP-dependent
  and ADP-producing reaction [[cite:PUB00066834]]. 4-phosphopantoate--beta-alanine ligase catalyses the
  conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis
  pathway. It cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase activity
  [[cite:PUB00060435]].