id: Pfam:PF02130
pfam_id: PF02130
name: Endoribonuclease YbeY
short_name: YbeY
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02130
counters:
  proteins: 20178
  matches: 20283
  proteomes: 19123
  taxa: 29306
  structures: 5
  alphafold_models: 13642
  domain_architectures: 53
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR002036
description: YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome
  quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase
  R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits,
  by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of
  16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of
  16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs [[cite:PUB00064743],[cite:PUB00064742],[cite:PUB00096939]].
  The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one
  central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices [[cite:PUB00027806]].